Thermo Fisher Scientific MPRIP Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MPRIP. Recombinant protein control fragment (Product #RP-93317).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644088

Product Specific Information

Immunogen sequence: RVEGHVGELG DFQVKNSQAL MCLENCREQL RSLPRASQED EQDARAASLA SVESALVSAI QALQHWPAPA HGGARAQLET GGTEENGKPA SLQQCSQSEL TEQEQVRLLS DQIALEASLI SQIADSLKNT T

Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 63%.

Target Information

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.