Thermo Fisher Scientific MECR Polyclonal Antibody
Human MECR 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MECR. Recombinant protein control fragment (Product # RP-93134). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643839 |
Product Specific Information
Immunogen sequence:
VRALVYGHHG DPAKVVELKN LELAAVRGSD VRVKMLAAPI NPSDINMIQG NYGLLPELPA VGGNEGVAQV VAVGSNVTGL KPGDWVIPAN AGLGTWRTEA VFSEEALIQV
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 89%
Target Information
The mitochondrial trans-2-enoyl-CoA reductase (MECR), initially identified as nuclear receptor-binding factor 1 (NRBF1), interacts with multiple nuclear hormone receptors in the presence of respective ligands. MECR is part of the mitochondrial fatty acid synthesis (FAS II) system and catalyzes the NADPH-dependent reduction of 2-enoyl thioesters, generating saturated acyl groups. Overexpression in transgenic mice can lead to cardiac abnormalities, suggesting that dysregulated FAS II gene expression may contribute to hereditary cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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