Thermo Fisher Scientific ABCA5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ABCA5. Recombinant protein control fragment (Product #RP-93359). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ABCA5,uniProtId:Q8WWZ7-1,ncbiNodeId:9606,antigenRange:54-127,antigenLength:1642,antigenImageFileName:PA5-54557_ABCA5_Q8WWZ7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54557_ABCA5_Q8WWZ7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637525

Product Specific Information

Immunogen sequence: PNKKYEEVPN IELNPMDKFT LSNLILGYTP VTNITSSIMQ KVSTDHLPDV IITEEYTNEK EMLTSSLSKP SNFV

Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

Target Information

ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes. Ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver and placenta, ABCA5 is a multi-pass membrane protein that contains two ABC transporter domains and exists as three alternatively spliced isoforms. ABCA5 exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site. ABCA5 is the first of five ABC1 family members that maps to human chromosome 17q24. ABCA5 is linked to lysosomal diseases and may play a role in tumor development and cardiomyocyte and follicular cell activities. ABCA5 might also be a specific urine marker for diagnosis of patients with high-grade prostatic intraepithelial neoplasia (HGPIN).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.