Thermo Fisher Scientific LPHN1 Polyclonal Antibody
Thermo Fisher Scientific의 LPHN1 Polyclonal Antibody는 인간 LPHN1 단백질을 인식하는 토끼 다클론 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 신경세포 신호전달 및 세포 접착 관련 연구에 적합합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human LPHN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 15 mM sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719539 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, a neurotoxin in black widow spider venom that induces massive exocytosis in neurons and neuroendocrine cells.
Adgrl1 acts as a receptor for TENM2, mediating heterophilic synaptic cell-cell contact and postsynaptic specialization, and may regulate exocytosis.
The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCRs), functioning in both cell adhesion and signal transduction.
Proteolytic cleavage within the cysteine-rich GPS domain produces two non-covalently bound subunits at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synaptic plasma membrane, and alternative splicing generates multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Late-Onset Autosomal Dominant Retinal Degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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