Thermo Fisher Scientific LPHN1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, a neurotoxin in black widow spider venom that induces massive exocytosis in neurons and neuroendocrine cells.
Adgrl1 acts as a receptor for TENM2, mediating heterophilic synaptic cell-cell contact and postsynaptic specialization, and may regulate exocytosis.
The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCRs), functioning in both cell adhesion and signal transduction.
Proteolytic cleavage within the cysteine-rich GPS domain produces two non-covalently bound subunits at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synaptic plasma membrane, and alternative splicing generates multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Late-Onset Autosomal Dominant Retinal Degeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.