Thermo Fisher Scientific Human ZNF350 Synthetic Peptide
인간 ZNF350(ZBRK1) 단백질의 C-말단 20개 아미노산으로 구성된 합성 펩타이드입니다. 항체 PA5-20614의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS(pH 7.2, 0.1% BSA) 완충액에 보관됩니다. 연구용으로만 사용됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the carboxy terminus of human ZBRK1.
PEP-0734 can be used as a blocking peptide with polyclonal antibody PA5-20614.
Target Information
ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) family of transcriptional repressors. It is up-regulated in senescent fibroblasts and interacts with BRCA1, a transcriptional regulator with tumor suppressor activity.
ZBRK1 binds to a specific sequence within the GADD45 gene, forming a nuclear complex with BRCA1 to repress transcription.
It can homo-oligomerize through a C-terminal transcriptional repression domain (CTRD), facilitating transcriptional repression via ZBRK1 response elements.
These findings suggest that higher-order ZBRK1 oligomers assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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