Thermo Fisher Scientific CST1 Polyclonal Antibody

Thermo Fisher Scientific CST1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.

• Type 1 cystatins (A and B): Mainly intracellular.
• Type 2 cystatins (C, D, E/M, F, G, S, SN, SA): Extracellular.
• Type 3 cystatins (kininogens): Intravascular proteins.

All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are primarily found in saliva, but S and SN are also expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate inhibition of cathepsin proteins.
Fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis, bone resorption, insulin and hepatocyte growth factor receptor regulation, and systemic inflammation response.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced thrombocyte aggregation.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.