Thermo Fisher Scientific TNP2 Polyclonal Antibody
TNP2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 랫드 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human TNP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719431 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
During mammalian spermiogenesis, histones are transiently replaced by several low molecular weight proteins called transition proteins (TNPs). These proteins facilitate chromatin transformation from the nucleosome to the nucleoprotamine structure during spermatid differentiation.
Transition protein-2 (TNP2), also known as TP2, maps to human chromosome 16p13.13 and encodes a highly basic nuclear protein. TNP2 is a spermatid-specific product of the haploid genome that replaces histones and is later replaced by protamines in mature sperm.
Although TNP2 is not essential for sperm nuclear shaping, histone displacement, or fertility, it is required for proper processing of protamine 2 and completion of chromatin condensation. In the absence of TNP1, TNP2 may partially compensate, but this imbalance can result in abnormal chromatin condensation and reduced fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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