Thermo Fisher Scientific DR4 Monoclonal Antibody (32A1380)
DR4 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 합성 펩타이드(2-21 aa, human DR4)로부터 유래. 단백질 G 정제, PBS에 0.05% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:20–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 32A1380 |
| Immunogen | Synthetic peptide corresponding to residues 2–21 of human DR4 mature protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1088002 |
Product Specific Information
- Suggested positive control: Daudi cells.
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. Its ligand, TRAIL, is a member of the TNF family. DR4 mediates apoptosis and NF-κB activation in various cells and tissues. Apoptosis, or programmed cell death, plays a critical role in normal cellular differentiation and development. It is induced by cytokines of the TNF family (e.g., TNF, Fas ligand) and their corresponding death domain-containing receptors (e.g., TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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