Thermo Fisher Scientific MEP1B Polyclonal Antibody
Human MEP1B 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. Western blot, IHC, IP 실험에 적합하며 높은 특이성과 재현성을 제공. 항원 친화 크로마토그래피로 정제되어 안정적인 결과를 보장.
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Applications
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (IHC) | 5–15 µg/mL | - |
| Immunoprecipitation (IP) | 25 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Meprin beta Subunit/MEP1B (Leu21–Ser593) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607664 |
Product Specific Information
In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant mouse MEP1B is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Meprins are multidomain zinc metalloproteases highly expressed in mammalian kidney and intestinal brush border membranes, leukocytes, and certain cancer cells. They hydrolyze various peptide and protein substrates and are implicated in cancer and intestinal inflammation.
Mature meprins form oligomers of separately encoded alpha and beta subunits. Homooligomers of alpha subunit are secreted, while oligomers containing the beta subunit are plasma membrane-bound.
The MEP1B gene encodes the beta subunit, and its disruption in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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