Thermo Fisher Scientific DNAJB2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LTGTGTGPSR AEAGSGGPGF TFTFRSPEEV FREFFGSGDP FAELFDDLGP FSELQNRGSR HSGPFFTFSS SFPGHSDFSS SSFSFSPGAG AFRSVS

Highest antigen sequence identity to the following orthologs:

• Mouse: 85%
• Rat: 86%

Target Information

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from Escherichia coli and are under the control of the htpR regulatory protein.

DnaJ proteins play a critical role in the HSP70 chaperone machine by interacting with HSP70 to stimulate ATP hydrolysis. The proteins contain cysteine-rich regions composed of zinc fingers that form a peptide-binding domain responsible for chaperone function.

DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis, and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.