Thermo Fisher Scientific CaBP8 Polyclonal Antibody
Human CaBP8 단백질을 인식하는 Rabbit 폴리클로날 항체로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 0.3 mg/mL 농도의 액상 형태. CaBP8 관련 세포 내 칼슘 신호 전달 연구에 활용 가능.
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Thermo Fisher Scientific CaBP8 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CaBP8. Recombinant protein control fragment (Product #RP-96585). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639211 |
Product Specific Information
Immunogen sequence:
FDEFMTILGP KLVSSEGRDG FLGNTIDSIF WQFDMQRITL EELKHILYHA FRDHLTMKDI E
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
Calcium binding proteins (CaBP) play a crucial role in calcium-mediated cellular signal transduction in the central nervous system. The CaBP family shares similarity with calmodulin (CaM I) and can functionally substitute or augment CaM I activity.
CaBP8 contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess unique targeting mechanisms among CaBPs that may contribute to differential Ca²⁺ sensing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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