Thermo Fisher Scientific Phospho-PI3K p85 alpha (Tyr508) Polyclonal Antibody
PI3K p85 alpha 단백질의 Tyr508 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 고순도 액상 형태로 제공. Human, Mouse, Rat 시료에 반응하며 연구용으로 사용.
- 카탈로그번호
- PA5105116
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PIK3R1 (Accession P27986), corresponding to amino acid residues around phosphorylated Tyr508 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816589 |
Product Specific Information
Antibody detects endogenous levels of PI3K p85 alpha only when phosphorylated at Tyr508.
Target Information
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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