Thermo Fisher Scientific SCF Polyclonal Antibody

Applications

• Western Blot (WB): 3–5 µg/mL

Product Specifications

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression induces mast cell survival and promotes the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway decreases histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting potential therapeutic relevance in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.