Thermo Fisher Scientific GGCX Polyclonal Antibody
Thermo Fisher Scientific의 GGCX Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot, IHC, ELISA, IP에 적합합니다. Rabbit IgG 폴리클로날 항체로 합성 펩타이드(aa 400-450)를 면역원으로 사용하며, 액상 형태로 -20°C에서 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 400–450 on human GGCX protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates the vitamin K-dependent carboxylation of glutamate residues on target proteins, producing calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and is essential for the activity of all vitamin K-dependent proteins, including blood coagulation and bone matrix proteins.
Defects in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, characterized by abnormal skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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