Thermo Fisher Scientific GGCX Polyclonal Antibody, Biotin
GGCX 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 Rabbit Polyclonal 항체입니다. Western blot, IHC, ELISA, IP에 사용 가능하며, 인간·마우스·랫트 반응성을 보입니다. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 연구용에 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 400–450 on human GGCX protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758-amino-acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates vitamin K-dependent carboxylation of glutamate residues on target proteins, producing calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and modifies glutamate residues to enable post-translational activation of vitamin K-dependent proteins such as blood coagulation and bone matrix proteins.
Defects in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, characterized by abnormal skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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