Thermo Fisher Scientific PDE6G Monoclonal Antibody (OTI1E11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The second messengers cAMP and cGMP are key regulatory molecules involved in numerous signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs).
PDE6 acts as the effector enzyme in the G protein-mediated signal transduction cascade of the visual system. It consists of multiple subunits: cone-specific catalytic subunit alpha′, rod-specific catalytic subunits alpha and beta, inhibitory subunit gamma, and subunit delta.
The catalytic core forms alpha′/alpha′ homodimers in cones and alpha/beta heterodimers in rods. The C-termini of both catalytic and inhibitory subunits undergo post-translational modifications such as methylation, myristoylation, and prenylation, which are essential for proper complex assembly and membrane association.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.