Thermo Fisher Scientific PRMT2 Monoclonal Antibody (OTI1A2), TrueMAB
PRMT2 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI1A2). Western blot과 Immunocytochemistry에 적합. HEK293T 세포에서 발현된 full-length human PRMT2 항원을 면역원으로 사용. 동결건조 형태, PBS buffer에 8% trehalose 함유, 보존제 없음.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A2 |
| Immunogen | Full length human recombinant protein of human PRMT2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach approximately 1 mg/mL antibody concentration.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PRMT2 (Protein Arginine Methyltransferase 2) is an arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4.
Acts as a coactivator with NCOA2 for androgen receptor (AR)-mediated transactivation and with estrogen for estrogen receptor (ER)-mediated transactivation.
Enhances PGR, PPARG, and RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity in an RB1-dependent manner and may be involved in growth regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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