Thermo Fisher Scientific Phospho-ATR (Ser428) Polyclonal Antibody
Phospho-ATR (Ser428) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응. Western blot, IHC, ICC, ELISA에 적합. DNA 손상 반응 및 세포주기 체크포인트 연구용. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914867 |
Product Specific Information
Positive test controls include NIH/3T3.
The target is usually found in the following locations: Chromosome, Nucleus, PML body.
Immunogen sequence: DGISPK
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress.
It phosphorylates and activates several proteins involved in the inhibition of DNA replication and mitosis, promoting DNA repair, recombination, and apoptosis.
This protein is also important for fragile site stability and centrosome duplication.
Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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