Thermo Fisher Scientific Phospho-Tau (Ser202) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

The target is usually found in the following locations:

• Cell membrane
• Cell projection
• Cytoplasm
• Cytoplasmic side
• Peripheral membrane protein
• Axon
• Cytoskeleton
• Cytosol

Immunogen sequence: PGSPG

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is predetermined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.
Short isoforms allow cytoskeletal plasticity; longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brain.
Hyper-phosphorylation impairs microtubule binding, destabilizing microtubules and leading to neuronal degeneration.
Tau is phosphorylated by multiple kinases including GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is found in neurofibrillary lesions in Alzheimer’s disease and other CNS disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.