Thermo Fisher Scientific Phospho-AEG1 (Ser568) Polyclonal Antibody
Phospho-AEG1 (Ser568) 폴리클로날 항체로, 인간·생쥐·쥐·소 시료에 반응합니다. Western blot과 IHC(파라핀) 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포막 위치 단백질 검출에 유용하며, 연구용으로만 사용됩니다.
- 카탈로그번호
- 630-080
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-AEG1 (Ser568) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from phosphorylation site of serine 568 surrounding the epitope -TSWESPKQI- of human AEG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HeLa cells treated with TNF-alpha
- Cellular location: Cell membrane
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation rather than serving as a structural component.
Metadherin is overexpressed in breast cancer tissue and xenografts, whereas normal breast tissue shows low expression. It binds to lung vasculature, a common site of breast cancer metastasis, through a C-terminal extracellular domain segment. Antibody blocking or siRNA inhibition of metadherin has been reported to suppress breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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