Thermo Fisher Scientific CD209 (DC-SIGN) Monoclonal Antibody (eB-h209), Biotin, eBioscience
인간 CD209(DC-SIGN)을 인식하는 Biotin 결합 단일클론 항체로, 유세포분석(Flow Cytometry)에 적합합니다. DC-SIGN의 발현 연구 및 HIV 관련 면역반응 분석에 활용됩니다. 0.5 mg/mL 농도의 액상 제품으로 4°C 보관이 권장됩니다.
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Applications
Tested Application
- Flow Cytometry (Flow)
Tested Dilution
- 1 µg/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eB-h209 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466648 |
Additional Formats Available
Product Specific Information
The eB-h209 monoclonal antibody reacts with human CD209 (DC-SIGN), a 44 kDa type II transmembrane protein containing a C-type lectin binding domain. DC-SIGN binds ICAM-3, ICAM-2, and HIV virus, and is preferentially expressed on human dendritic cells. It is suggested to function as a receptor for HIV capture and transmission to T cells, supporting the primary immune response. The antibody was developed against a C-terminal peptide of human DC-SIGN.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Tested by flow cytometry on cultured human dendritic and peripheral blood cells
- Recommended ≤ 1 µg per test (100 µL final volume)
- Cell number: 10⁵–10⁸ cells/test
- Optimize titration for best performance
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
The CD209 gene encodes a transmembrane receptor (DC-SIGN) expressed on dendritic cells and macrophages. It plays a key role in the innate immune system by recognizing a wide range of pathogens including parasites and viruses. The protein has three main domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region functions as both a pathogen recognition and cell adhesion receptor. The neck domain allows homo-oligomerization, increasing binding avidity to multivalent ligands. Variations in the neck domain repeat number can affect ligand binding. CD209 is closely related to L-SIGN (GeneID 10332), differing in ligand-binding properties and tissue distribution. Alternative splicing results in multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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