Thermo Fisher Scientific CSF1R Monoclonal Antibody (1G4)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the CSF1R gene are associated with predisposition to myeloid malignancy.
It acts as a cell-surface receptor for CSF1 and IL34, regulating survival, proliferation, and differentiation of hematopoietic precursor cells, especially macrophages and monocytes. It promotes release of proinflammatory chemokines in response to IL34 and CSF1, playing an important role in innate immunity and inflammatory processes.
The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.