Thermo Fisher Scientific CSNK1E Monoclonal Antibody (2E1)
CSNK1E 단백질을 인식하는 Mouse IgG2a 단클론 항체로, 인간 시료에 반응합니다. ICC/IF, ELISA, in situ PLA 등에 사용 가능하며, 액상 형태로 제공됩니다. 연구용으로만 사용되며, -20°C에서 보관해야 합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E1 |
| Immunogen | CSNK1E (NP_689407, 2 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ELRVGNKYRL GRKIGSGSFG DIYLGANIAS GEEVAIKLEC VKTKHPQLHI ESKFYKMMQG GVGIPSIKWC GAEGDYNVMV MELLGPSLED LFNFCSRKF
Target Information
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis.
CSNK1E phosphorylates key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways.
CK1 family members share a highly conserved kinase domain but differ in their variable N- and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon.
CK1ε positively regulates Akt possibly by inhibiting PP2A and plays an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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