Thermo Fisher Scientific MELK Polyclonal Antibody
MELK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 암 연구 및 세포주기 조절 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human Maternal Embryonic Leucine Zipper Kinase (MELK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
MELK (Maternal Embryonic Leucine Zipper Kinase) is a serine/threonine kinase related to the AMPK family and is linked to cell cycle regulation. It is often overexpressed in cancers and is a potential target for cancer therapeutics. MELK phosphorylates multiple substrates including BCL2L14, CDC25B, MAP3K5/ASK1, and ZNF622, contributing to apoptosis activation, cell cycle regulation, and carcinogenesis. It is essential for the proliferation of embryonic and postnatal neural progenitors and may also play a role in primitive hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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