Thermo Fisher Scientific RNF144B Monoclonal Antibody (OTI10A12), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

RNF144B is an E3 ubiquitin-protein ligase that transfers ubiquitin from E2 conjugating enzymes (UBE2L3, UBE2L6) to substrates such as LCMT2, promoting their degradation.
It induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Overexpression can reduce the stability of BAX, a pro-apoptotic protein, leading to protection against cell death, although RNF144B itself is not anti-apoptotic.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.