Thermo Fisher Scientific RNF144B Monoclonal Antibody (OTI10A12), TrueMAB
Human RNF144B 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 동결건조 형태이며, PBS buffer에 trehalose 함유. 연구용으로만 사용되며, 재구성 및 결합 실험에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10A12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–256 of human RNF144B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
RNF144B is an E3 ubiquitin-protein ligase that transfers ubiquitin from E2 conjugating enzymes (UBE2L3, UBE2L6) to substrates such as LCMT2, promoting their degradation.
It induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Overexpression can reduce the stability of BAX, a pro-apoptotic protein, leading to protection against cell death, although RNF144B itself is not anti-apoptotic.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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