Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Arg3.1/ARC 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, 합성 펩타이드 항원으로 제작되었습니다. 장기 보관 시 -20°C에서 안정적이며 연구용으로 사용됩니다.
- 카탈로그번호
- OSA00061G-500UG
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 5 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat Arg3.1 (ARC) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Arg3.1/ARC.
Target Information
Arg3.1/ARC is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs, mediating intercellular RNA transfer in the nervous system. ARC is released from neurons via extracellular vesicles, transferring ARC mRNA to new target cells where translation occurs in an activity-dependent manner.
ARC capsids are endocytosed and deliver mRNA into neuronal cytoplasm, functioning as a key regulator of synaptic plasticity, required for long-term potentiation (LTP), long-term depression (LTD), and long-term memory formation.
It promotes endocytosis of AMPA receptors (AMPARs) in response to synaptic activity, maintaining receptor levels through synaptic scaling. ARC also mediates synapse elimination in developing cerebellum and contributes to neuronal homeostasis.
Additionally, ARC participates in postsynaptic trafficking and processing of amyloid-beta (APP) and is expressed in skin-migratory dendritic cells, regulating dendritic cell migration and T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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