Thermo Fisher Scientific extracellular ASIC1 Polyclonal Antibody
ASIC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트에 반응하며, 합성 펩타이드 항원을 기반으로 제작되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 100–150 of the extracellular domain of rat ASIC1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and human.
- Specificity of this antibody: ASIC1.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels with intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop containing many cysteine residues with conserved spacing.
ASIC1 is expressed in most brain neurons and may function as an ion channel subunit. It acts as a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampus, amygdala, cerebellum, and other brain areas. Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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