Thermo Fisher Scientific SIRT2 Polyclonal Antibody
SIRT2 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 반응성을 가집니다. Western blot 및 Immunocytochemistry에 적합하며 SIRT2의 341-352 아미노산 서열을 면역원으로 사용합니다. 종양 억제 및 세포주기 연구에 활용 가능합니다.
- 카탈로그번호
- PA3200
- 판매단위
- pk
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Thermo Fisher Scientific SIRT2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:400 | View 1 publication |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Horse, Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: D(341) E A R T T E R E K P Q(352) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2188496 |
Product Specific Information
PA3-200 detects human and rat SIRT2 and shows no cross-reactivity to other SIRT isoforms.
It has been successfully used in Western blot and immunocytochemistry procedures.
By Western blot, this antibody detects an ~48 kDa protein representing SIRT2 from SAOS2 cells.
The immunizing peptide corresponds to amino acid residues 341–352 from the human SIRT2 protein, a sequence completely conserved between human and rat.
Target Information
SIRT2 (Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacetylase (NDAC) involved in gene silencing, cell cycle control, and DNA damage repair.
It may act as a tumor suppressor in human gliomas and serve as a molecular marker for these cells.
SIRT2 also functions as a redox sensor regulating muscle gene expression in response to food intake and exercise.
During mitosis, SIRT2 participates in the phosphorylation cascade, being phosphorylated in late G2 phase, M phase, and cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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