Thermo Fisher Scientific Phospho-Aurora B (Thr198) Polyclonal Antibody
Aurora B 단백질의 Thr198 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot과 ELISA에 최적화되어 있으며, Human, Mouse, Rat 시료에 반응. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Aurora B around the phosphorylation site of Thr232 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aurora kinases are associated with microtubules during chromosome movement and segregation. Aurora B (AURKB) localizes to microtubules near kinetochores, particularly to K-fibers. This complex is involved in chromosome alignment, separation, histone modification, and cytokinesis. The chromosomal passenger complex (CPC) includes INCENP, survivin, and borealin, which regulate Aurora B activity and localization. Aurora B is often overexpressed in tumors such as breast and colon cancers, and its expression correlates with Aurora-A kinase, suggesting a feedback relationship.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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