Thermo Fisher Scientific Human TLK1, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: N/A

Product Specifications

Product Specific Information

For maximum recovery, spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Do not store kinase diluted.
If properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Features:

• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product: LanthaScreen™ Eu Kinase Binding Assay

Protein Form: Recombinant
Gene Accession Number: NP_036422.3

Target Information

TLK1 (Tousled-like kinase 1) is a nuclear serine/threonine kinase involved in chromatin assembly regulation.
Originally described in Arabidopsis, TLK1 is a novel target of the DNA damage checkpoint and is rapidly inactivated upon exposure to ionizing radiation, mediated by the S-phase DNA damage checkpoint.
Suppression of TLK1 activity after DNA double-strand breaks, replication blockade, or UV irradiation requires ATM, NBS, and CHK1.
Tousled-like kinases are nuclear serine/threonine kinases potentially involved in chromatin assembly regulation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.