Thermo Fisher Scientific RNF157 Polyclonal Antibody
Rabbit polyclonal antibody against human RNF157 protein. Recognizes E3 ubiquitin ligase involved in neuronal survival and dendrite maintenance. Supplied in liquid form, unconjugated, and stored at 4°C or -20°C. For research use only.
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- PA554926
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Thermo Fisher Scientific RNF157 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNF157 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646636 |
Product Specific Information
Immunogen sequence:
PIISSQTSDS EEHPSSENIP PGYEVVSLLE ALNGPLTPSP AVPPLHVLGD GHLSGMLPSY GSDGHLPPVR TISPLDRLSD SSSQGLOrtholog sequence identity:
Mouse - 92%, Rat - 92%
Target Information
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469).
Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469).
May act as a scaffold molecule to regulate this process (PubMed:25342469).
Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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