Thermo Fisher Scientific AF4 Polyclonal Antibody
Human AF4 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of human proto-oncogene AF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias.
The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor, in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors.
MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia.
The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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