Thermo Fisher Scientific MAP4K2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MAP4K2. Recombinant protein control fragment (Product #RP-89768). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MAP4K2,uniProtId:Q12851-1,ncbiNodeId:9606,antigenRange:344-452,antigenLength:820,antigenImageFileName:PA5-52422_MAP4K2_Q12851-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52422_MAP4K2_Q12851-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643743

Product Specific Information

Immunogen sequence: ETDPLNEPWE EEWTLLGKEE LSGSLLQSVQ EALEERSLTI RSASEFQELD SPDDTMGTIK RAPFLGPLPT DPPAEEPLSS PPGTLPPPPS GPNSSPLLPT AWATMKQRE

Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.

Target Information

MAP4K2 (GCK) is a serine/ threonine protein kinase that activates the JNK pathway. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. The kinase may also play a role in the regulation of vesicle targeting or fusion. The protein encoded by MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.