Thermo Fisher Scientific GALE Polyclonal Antibody
Thermo Fisher Scientific의 GALE Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 안정적인 액상 형태와 높은 특이성을 제공합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GALE. Recombinant protein control fragment (Product #RP-88675). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641830 |
Product Specific Information
Immunogen sequence:
QGIPNNLMPY VSQVAIGRRE ALNVFGNDYD TEDGTGVRDY IHVVDLAKGH IAALRKLKEQ CGCRIYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE GDVAA
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 97%
Target Information
This gene encodes UDP-galactose-4-epimerase, which catalyzes the epimerization of UDP-glucose to UDP-galactose and UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
The enzyme’s bifunctional nature means mutant cells depend on exogenous galactose and N-acetylgalactosamine for glycoprotein and glycolipid synthesis.
Mutations result in epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, cataracts, deafness, and mental retardation, with severity ranging from mild (peripheral form) to severe (generalized form).
Multiple alternatively spliced transcripts encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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