Thermo Fisher Scientific PTGER2 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 2–7 µg/mL

Product Specifications

Product Specific Information

PA1-32674 detects PTGER2 from human samples.

Target Information

Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal, and reproductive systems as well as smooth muscle.

It is also one of the most abundant of the prostanoid family in the brain, where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are four subtypes of EP receptors: EP1, EP2, EP3, and EP4.

EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptor is involved with the contraction and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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