Thermo Fisher Scientific PTGER2 Polyclonal Antibody
Rabbit polyclonal antibody against human PTGER2 (Prostaglandin E Receptor EP2). Validated for IHC (Paraffin) with 2–7 µg/mL dilution. Unconjugated, liquid form, 1 mg/mL concentration. Suitable for research use only, not for diagnostic procedures.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2–7 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Prostaglandin E Receptor EP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2174893 |
Product Specific Information
PA1-32674 detects PTGER2 from human samples.
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal, and reproductive systems as well as smooth muscle.
It is also one of the most abundant of the prostanoid family in the brain, where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are four subtypes of EP receptors: EP1, EP2, EP3, and EP4.
EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptor is involved with the contraction and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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