Thermo Fisher Scientific GCH1 Monoclonal Antibody (OTI5A1), TrueMAB
GCH1 단클론 항체(OTI5A1)는 인간, 마우스, 랫트 반응성을 가지며 Western blot 및 IHC(P) 실험에 적합합니다. 동결건조 형태로 제공되며, PBS 완충액에 8% 트레할로스를 포함합니다. 연구용으로만 사용되며, 재구성 및 결합 실험에 용이합니다.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A1 |
| Immunogen | Full length human recombinant protein of human GCH1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The GCH1 gene encodes a member of the GTP cyclohydrolase family. This enzyme catalyzes the conversion of GTP into 7,8-dihydroneopterin triphosphate, serving as the rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis.
BH4 acts as an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases.
Mutations in GCH1 are linked to malignant hyperphenylalaninemia and dopa-responsive dystonia.
Several alternatively spliced transcript variants exist, though not all produce functional enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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