Thermo Fisher Scientific MLH1 Monoclonal Antibody (OTI3D1), TrueMAB
MLH1 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat에 반응. Lyophilized 형태로 제공되며, PBS buffer에 trehalose 포함. DNA mismatch repair 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–527 of human MLH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic stability. Defects in mismatch repair pathways can lead to microsatellite instability (MSI), which is associated with carcinogenesis. Mutations in MLH1 are implicated in hereditary nonpolyposis colon cancer (HNPCC). MLH1, together with PMSH and MSH2, participates in the recognition and repair of mismatched nucleotides during DNA replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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