Thermo Fisher Scientific Human JAKMIP1 Synthetic Peptide

Thermo Fisher Scientific Human JAKMIP1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the center of human JAKMIP1.
PEP-1537 can be used as a blocking peptide with polyclonal antibody PA5-34495.

Target Information

JAKMIP1, also known as Marlin-1, is a highly conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulates microtubule cytoskeleton rearrangements.
JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules.
Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung, and skeletal muscle, while isoforms 2–4 are specifically expressed in brain and retina.
JAKMIP1 participates in polarized secretion in lymphocytes and has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity.
Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.