Thermo Fisher Scientific Human CRB2 Synthetic Peptide

Thermo Fisher Scientific Human CRB2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human CRB2.
PEP-1534 can be used as a blocking peptide with polyclonal antibody PA5-34492.

Target Information

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain, and kidney.
Along with other proteins, the Crumbs proteins form a complex that helps establish cell polarity in developing neuroepithelial cells.
At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes.
Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins.
Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.