Thermo Fisher Scientific VDAC Recombinant Rabbit Monoclonal Antibody (SA93-03)
Recombinant rabbit monoclonal antibody targeting human VDAC1. Validated for WB, IHC-P, and Flow Cytometry with high specificity. Expressed in HEK293 cells and purified via Protein A. Suitable for research use in apoptosis and mitochondrial studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SA93-03 |
| Immunogen | Synthetic peptide within N-terminal human VDAC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898842 |
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. They are located in the mitochondrial outer membrane and also expressed in the plasma membrane.
At least three different VDAC genes have been identified in vertebrates. VDAC proteins play an essential role in cellular metabolism and in the early stages of apoptosis.
VDAC constitutes a major pathway for metabolite exchange (ADP/ATP, succinate, citrate) between the cytosol and mitochondria.
VDAC1 in the plasma membrane provides a novel level of apoptosis regulation, potentially through its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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