Thermo Fisher Scientific NOX4/NADPH Oxidase 4 Monoclonal Antibody (NOX4, 1245)
인간 NOX4 단백질을 인식하는 Mouse IgG2b 단일클론 항체입니다. Western blot에 최적화되어 있으며 비결합형 형태로 제공됩니다. 단백질 A/G로 정제되어 높은 순도와 재현성을 보장합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 50507-MSM1-P1
- 판매단위
- pk
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Thermo Fisher Scientific NOX4/NADPH Oxidase 4 Monoclonal Antibody (NOX4, 1245)
Applications
- Western Blot (WB)
Tested Dilution: 1–2 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NOX4, 1245 |
| Immunogen | Recombinant human NOX4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.
NOX4 acts as a redox messenger in activating intracellular signaling pathways contributing to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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