Thermo Fisher Scientific PRRX1 Polyclonal Antibody
PRRX1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간·마우스·랫트 반응성. 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRRX1 (Accession P54821), corresponding to amino acid residues A53–S103 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854368 |
Product Specific Information
Antibody detects endogenous levels of total PRRX1.
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species, functioning to bind DNA via a helix-turn-helix structure and playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates the transcriptional activity of creatine kinase-M (muscle), contributing to mesodermal muscle type establishment.
PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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