Thermo Fisher Scientific NUSAP1 Polyclonal Antibody
Thermo Fisher Scientific의 NUSAP1 Polyclonal Antibody는 인간 및 생쥐 시료에서 NUSAP1 단백질을 검출하기 위한 고품질 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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- PA5106697
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NUSAP1 (Accession Q9BXS6), corresponding to amino acid residues V351–K401 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854365 |
Product Specific Information
Antibody detects endogenous levels of total NUSAP1.
Target Information
Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), polymer linked via different Lys residues (polyubiquitin chains), or linear polymer linked via the initiator Met (linear polyubiquitin chains).
Polyubiquitin chains have distinct functions depending on the Lys residue linkage:
- Lys-6-linked: DNA repair
- Lys-11-linked: ERAD and cell-cycle regulation
- Lys-29-linked: Lysosomal degradation
- Lys-33-linked: Kinase modification
- Lys-48-linked: Proteasomal degradation
- Lys-63-linked: Endocytosis, DNA damage response, NF-κB activation
Linear polymer chains (Met-linked) are involved in cell signaling. Ubiquitin is usually conjugated to Lys residues, but rare conjugations to Cys or Ser have been observed. Free polyubiquitin also plays roles in activation of protein kinases and signaling.
60S ribosomal protein L40 is a component of the 60S ribosomal subunit, essential for translation of a subset of cellular transcripts, particularly for cap-dependent translation of vesicular stomatitis virus mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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