Thermo Fisher Scientific NUSAP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NUSAP1.

Target Information

Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), polymer linked via different Lys residues (polyubiquitin chains), or linear polymer linked via the initiator Met (linear polyubiquitin chains).
Polyubiquitin chains have distinct functions depending on the Lys residue linkage:

• Lys-6-linked: DNA repair
• Lys-11-linked: ERAD and cell-cycle regulation
• Lys-29-linked: Lysosomal degradation
• Lys-33-linked: Kinase modification
• Lys-48-linked: Proteasomal degradation
• Lys-63-linked: Endocytosis, DNA damage response, NF-κB activation

Linear polymer chains (Met-linked) are involved in cell signaling. Ubiquitin is usually conjugated to Lys residues, but rare conjugations to Cys or Ser have been observed. Free polyubiquitin also plays roles in activation of protein kinases and signaling.

60S ribosomal protein L40 is a component of the 60S ribosomal subunit, essential for translation of a subset of cellular transcripts, particularly for cap-dependent translation of vesicular stomatitis virus mRNAs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.