Thermo Fisher Scientific TIM-3 Polyclonal Antibody
Rabbit polyclonal antibody for detection of human TIM-3; validated for WB and IHC(P). Antigen affinity purified, liquid form, 1 mg/mL concentration. Store at 4°C short term or -20°C long term. For research use only.
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- PA5114520
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TIM-3 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM-3. The immunogen is located within amino acids 60–110 of TIM-3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890358 |
Product Specific Information
Positive controls that may be used include: Jurkat Cell Lysate
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance development.
Pathological significance of TIM3 has been associated with experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and it enhances the severity of EAE in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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