Thermo Fisher Scientific beta Catenin Recombinant Mouse Monoclonal Antibody (GT2169)
Recombinant mouse monoclonal antibody targeting beta-Catenin (Clone GT2169). Validated for WB, IHC, and ICC/IF applications. High purity (Protein A purified), 1.6 mg/mL concentration. Suitable for research use in cell signaling and tumorigenesis studies.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | GT2169 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human beta Catenin (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094344 |
Target Information
Beta-catenin is an adherens junction (AJ) protein essential for epithelial cell layer formation and maintenance. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless signaling.
This protein plays a crucial role in morphogenesis and is expressed in various hair follicle and epithelial cell types. Dysregulation of beta-catenin has been implicated in diseases such as pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes like cyclin D and c-myc that drive cell proliferation, contributing to tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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