Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI1C6), TrueMAB
인간 TNFRSF8(CD30)에 특이적인 마우스 단클론 항체로, WB, IHC, Flow Cytometry에 적합. 고순도 Affinity Chromatography 정제, 안정적인 PBS/BSA/glycerol 저장용액. Hodgkin 림프종 및 CD30+ 세포 연구용.
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Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI1C6), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–379 of human TNFRSF8 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily.
Originally identified as a surface antigen of Hodgkin and Reed-Sternberg cells, CD30 binds to CD30L (CD153) and mediates various cellular effects including proliferation, activation, differentiation, and apoptosis.
CD30 plays a critical role in the pathophysiology of Hodgkin’s disease and other CD30+ lymphomas, and acts as a costimulatory molecule in thymic negative selection.
Expression is found on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas, virus-infected T/B cells, and activated normal T/B cells.
Soluble CD30 (sCD30) serves as a marker for Th2 immune response. TRAF2 and TRAF5 interact with CD30 to activate NF-κB signaling, regulating apoptosis and preventing autoimmunity.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported. CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as embryonal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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