Thermo Fisher Scientific DICER1 Monoclonal Antibody (OTI1D9), TrueMAB
인간 DICER1 단백질(aa 1666-1922)에 특이적인 Mouse IgG1 단클론 항체. IHC(P)에서 1:150 희석으로 검증됨. Affinity chromatography로 정제된 액상 제품으로, RNA 간섭 관련 연구에 적합. -20°C 보관, 동결/해동 반복 피할 것.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1666–1922 of human DICER1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Dicer is a double-stranded RNA (dsRNA) endoribonuclease that plays a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of 21–23 nucleotides with 3′ overhangs of two nucleotides, producing short interfering RNAs (siRNA) and mature microRNAs.
These siRNAs and miRNAs guide the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or inhibit translation.
Gene silencing mediated by siRNAs (RNA interference) controls elimination of transcripts from mobile and repetitive DNA elements and degradation of exogenous viral RNA.
The miRNA pathway specifically regulates expression of target genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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