Thermo Fisher Scientific HEF1 Monoclonal Antibody (14A11)
인간 HEF1 단백질을 검출하는 Mouse IgG2b 단클론 항체로, ICC/IF 및 IP 실험에 적합. Protein G 정제, 1 mg/mL 농도, PBS에 0.1% sodium azide 포함. 세포 이동성 및 암 관련 신호 연구용으로 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: 5 µg/mg whole cell lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 14A11 |
| Immunogen | GST fusion protein, corresponding to amino acids 82–398 of Human HEF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2149480 |
Product Specific Information
MA1-90001 detects HEF1 from human samples.
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation. The Cas family of docking proteins are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases, both active drug development targets. HEF1 overproduction increases mRNA levels of motility and invasiveness-related proteins, such as metalloproteinases, MLCK, p160ROCK, and ErbBi, and mediates apoptosis in epithelial cell lines (e.g., MCF7, HeLa). Overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance, emphasizing the role of this protein family in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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