Thermo Fisher Scientific UCH37 Recombinant Rabbit Monoclonal Antibody (7R9F9)
UCH37/UCHL5 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 재조합 HEK293 세포에서 발현되었으며, Protein A로 정제되었습니다. 고순도, 안정한 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7R9F9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–329 of human UCH37/UCHL5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.78 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR QLAEEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL KTLAEHQQLI PLVEKAKEKQ NAKKAQETK
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquitinated protein substrates. UCH-L5 can rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, potentially influencing tumor growth. Through association with Smad7, UCH-L5 upregulates TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, making them potential targets for cancer therapy. Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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