Thermo Fisher Scientific Neurokinin B receptor Polyclonal Antibody
Neurokinin B receptor를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며, Protein A로 정제된 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human NKR, amino acids 151–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tachykinins are a family of small peptides that include neurotransmitters such as substance P, neurokinin A, and neurokinin B. These act on three related but distinct seven-transmembrane G-protein-coupled receptors at varying concentrations. The NK-3 receptor (NK3R) has the highest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin. NK3R may play roles in learning and memory, as knockout mice exhibit cognitive deficits. It may also influence vagal afferent relay neurons, although activation in airway nerves is more likely mediated by substance P or neurokinin A rather than neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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